The Schuylkill River: never wise to drink directly from it. You’ll come down with some crazy rash. Or worse. But dining on it is another story entirely. The Water Works Restaurant and Lounge opens tomorrow, and its location in the historic Fairmount Water Works — a stunning neoclassical building erected in 1812 and situated on a picturesque cliff above the river — affords a breathtaking view. But first-time restaurateur Michael Karloutsos didn’t spend two and a half years remaking the landmark space just to give you a great vista. He hired former El Vez chef de cuisine Adan Trinidad to create a sophisticated, Mediterranean-themed menu. Dine on whole grilled fish or sous-vide vanilla lobster inside the high-ceilinged Engine House or on the breezy outdoor terrace. Not hungry? Sip a leisurely cocktail and listen to the water rush by. You’ll be going with the flow in no time. The Water Works Restaurant and Lounge, 640 Water Works Drive, on the Schuylkill, below the Art Museum (215-236-9000).